The motion comes just a few months right after the airline recommenced flights from Belfast Metropolis right after an absence of 11 years.
Ryanair operates routes to Malaga, Alicante, Krakow, Warsaw, Gdansk and Milan from Belfast Global.
A spokesman for the airport reported: “It is disappointing that Ryanair has now made a decision to withdraw functions from the entire Northern Eire current market at the close of Oct, owning variously experienced a presence in all a few area airports in recent years.
“It has been a tough time period for aviation and a time when consumers need some balance and faith in the Northern Eire air transport network.”
Before on Tuesday, chief executive Michael O’Leary reported the airline was established to strike its target of carrying involving 90m and 100m passengers for the calendar year to March 2021. It flew 149m passengers in the calendar year to March 2019.
Shares rose jumped two.1pc to €16.41 in London, valuing the airline at €18.6bn.